(Stroke. 2000;31:2369.)
© 2000 American Heart Association, Inc.
Original Contributions |
Outcomes of Early Endovascular Versus Surgical Treatment of Ruptured Cerebral Aneurysms
A Prospective Randomized Study
From the Departments of Neurosurgery (T.K., H.H., J.H., M.V.) and Clinical Radiology (R.V., T.S.), Kuopio University Hospital, Kuopio, Finland.
Correspondence to Timo Koivisto, MD, Department of Neurosurgery, Kuopio University Hospital, Puijonlaaksontie 2, SF-70211 Kuopio, Finland. E-mail timo.koivisto{at}kuh.fi
Background and Purpose—This prospective study was conducted to compare the outcomes of surgical clipping and endovascular treatment in acute (<72 hours) aneurysmal subarachnoid hemorrhage (SAH).
Methods—One hundred nine consecutive patients were randomly assigned to either surgical (n=57) or endovascular (n=52) treatment. Clinical and neuropsychological outcome was assessed at 3 and 12 months after treatment; MRI of the brain was performed at 12 months. Follow-up angiography was scheduled after clipping and 3 and 12 months after endovascular treatment.
Results—One year postoperatively, 43/41 (surgical/endovascular) patients had good or moderate recovery, 5/4 had severe disability or were in a vegetative state, and 9/7 had died (NS) according to intention to treat. Patients with good clinical recovery did not differ in their neuropsychological test scores. Symptomatic vasospasm (OR 2.47; 95% CI 1.45 to 4.19; P<0.001), poorer Hunt and Hess grade (OR 2.50; 95% CI 1.31 to 4.75; P=0.005), need for permanent shunt (OR 8.90; 95% CI 1.80 to 44.15; P=0.008), and larger size of the aneurysm (OR 1.22; 95% CI 1.02 to 1.45; P=0.032) independently predicted worsened clinical outcome regardless of the treatment modality. In MRI, superficial brain retraction deficits (P<0.001) and ischemic lesions in the territory of the ruptured aneurysm (P=0.025) were more frequent in the surgical group. Kaplan-Meier analysis (mean±SD follow-up 39±18 months) revealed equal survival in both treatment groups. No late rebleedings have occurred.
Conclusions—One-year clinical and neuropsychological outcomes seem comparable after early surgical and endovascular treatment of ruptured intracranial aneurysms. The long-term efficacy of endovascular treatment in preventing rebleeding remains open.
Key Words: cerebral aneurysm • clinical trials • embolization, therapeutic • subarachnoid hemorrhage • surgery
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