Published Online
on October 22, 2009

A more recent version of this article appeared on December 1, 2009

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Submitted on March 30, 2009
Revised on May 26, 2009
Accepted on June 4, 2009

Neuroimaging Demonstration of Evolving Small Vessel Ischemic Injury in Cerebral Amyloid Angiopathy

Ravi S. Menon MD^* and Chelsea S. Kidwell MD

From Department of Neurology and Stroke Center (R.S.M., C.S.K.), Georgetown University, Washington, DC; National Institute of Neurological Disorders and Stroke (R.S.M.), National Institutes of Health, Bethesda, Md; Stroke Center (R.S.M.), Washington Hospital Center, Washington, DC.

^* To whom correspondence should be addressed. E-mail: ravi.menon{at}gunet.georgetown.edu.

Background and Purpose—Cerebral amyloid angiopathy is a small to medium vasculopathy most commonly associated with symptomatic intracerebral hemorrhage and microbleeds.

Summary of Case—We present a patient with cerebral microbleeds and likely amyloid angiopathy with evolving ischemic lesions visualized on diffusion-weighted imaging.

Conclusions—This case captures with serial MRI the evolving and dynamic nature of cerebral amyloid angiopathy and particularly illustrates the subclinical, yet progressive, ischemic aspects of this vasculopathic process.

Key words: amyloid angiopathy • cerebrovascular disease